Bronchoalveolar carcinoma lung. Location: 13 locations, This clinical trial is an interventional, active-treatment, open-label, multi-center, Phase 1 / 2 study. Vulvar cancer (temporarily closed to accrual) 36. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 52). Our syndication services page shows you how. Pancreatic Cancer Clinical Trials New medications and treatments for pancreatic cancer must be shown to be safe and effective before doctors can prescribe them to patients. Location: 42 locations, This phase I trial studies the side effects and best dose of anetumab ravtansine when given together with nivolumab, ipilimumab and gemcitabine hydrochloride in treating patients with mesothelin positive pancreatic cancer that has spread to other places in the body (advanced). Find an NCI-supported clinical trial—and learn how to locate other research studies—that may be right for you or a loved one. Pancreatic Cancer is one of the most lethal malignancies and is the 3rd leading cause of death due to cancer in the United States. Location: 204 locations, This phase II trial studies whether adding pembrolizumab to olaparib (standard of care) works better than olaparib alone in treating patients with pancreatic cancer with germline BRCA1 or BRCA2 mutations that has spread to other places in the body (metastatic). Squamous cell carcinoma variants of the genitourinary (GU) system 19. Welcome to the Translational Research Program (TRP) The Translational Research Program (TRP) is the home of the SPOREs — the Specialized Programs of Research Excellence — a cornerstone of NCI’s efforts to promote collaborative, interdisciplinary translational cancer research. NCI also funds cross-cutting initiatives such as cancer centers and funds programs to develop a strong workforce of cancer … PARP inhibitors are a type of targeted therapy. All NCI Center for Cancer Research (CCR) clinical trials take place at the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland. The addition of pembrolizumab to the usual treatment of olaparib may help to shrink tumors in patients with metastatic pancreatic cancer with BRCA1 or BRCA2 mutations. When either of these genes is mutated, or altered, such that its protein product is not made or does not function correctly, DNA damage may not be repaired properly. NCI funds and oversees both early- and late-phase clinical trials … Intrahepatic cholangiocarcinoma (closed to accrual 03 / 20 / 2018) 10. Skip to main content 1-800-4-CANCER Live Chat Publications Dictionary The Pancreatic Cancer Action Network (PanCAN) is dedicated to fighting the world’s toughest cancer. Pancreatic Cancer Clinical Trials for Newest Therapies. Clinical trials are research studies that involve people. The programs listed below are a small sampling of NCI’s research efforts in pancreatic cancer. In each cohort, eligible patients will be assigned to one of several treatment arms. Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract.) Fibromixoma and low grade mucinous adenocarcinoma (pseudomixoma peritonei) of the appendix and ovary (closed to accrual 03 / 20 / 2018) 8. Established under the National Cancer Institute Act of 1937, NCI is part of the National … Start here to find information on pancreatic cancer treatment, research… Only 7% are expected to survive 5 years or longer because the disease is … The disease is very hard to detect early and currently there is no screening test available. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. Gestational trophoblastic disease (GTD) 47. NCI-funded researchers are working to advance our understanding of how to prevent, detect, and treat pancreatic cancer. Developing drugs that target mutant forms of RAS has proved challenging. Over 56,770 newly diagnosed cases and an estimated 45,750 deaths are expected in the … Some research is basic, exploring questions as diverse as the biological underpinnings of cancer and the social factors that affect cancer risk. Location: 12 locations, This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other parts of the body (advanced / metastatic) or cannot be removed by surgery (unresectable), including breast cancer, non-small cell lung cancer, small cell lung cancer, and pancreatic cancer. The National Cancer Institute (NCI) is the federal government's principal agency for cancer research and training. Location: 12 locations, The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab and determine the recommended Phase 2 dose (RP2D) of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab. Tumor of unknown primary (Cancer of Unknown Primary; CuP) (closed to accrual 12 / 22 / 2017) 33. Gemcitabine hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Talk to your doctor for help in deciding if one is right for you. The majority of pancreatic cancer research funding comes from the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH), the primary federal agency charged with biomedical research. Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. As a result, cells are more likely to develop additional genetic alterations that can lead to some types of cancer, including pancreatic cancer. BRCA1 and BRCA2 are human genes that produce tumor suppressor proteins. Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, Pancreatic Neuroendocrine Tumors Treatment, Pancreatic Cancer Detection Consortium (PCDC), Pancreatic Cancer Microenvironment Network (PaCMEN), Pancreatic Specialized Programs of Research Excellence (Pancreatic SPOREs), Boosting Dendritic Cells Helps the Immune System Find Pancreatic Cancer, To Treat Pancreatic Cancer, Mouse Study Suggests Altering Tumor Microbiome, Trial Highlights Complexities of Targeted Therapy for Pancreatic Cancer, Researchers Discover Potential Way to Hit Elusive Target in Pancreatic Cancer, Altering Chemotherapy Improves Outcomes in Early-Stage Pancreatic Cancer, FDA Approves New Treatment for Certain Neuroendocrine Tumors, Pancreatic Cancer Research Results and Study Updates, U.S. Department of Health and Human Services, The RAS genes make proteins that take part in signaling pathways that control cell growth. Anetumab ravtansine is a monoclonal antibody, called anetumab ravtansine, linked to a chemotherapy drug called DM4. Pancreatic cancer can form in exocrine cells and neuroendocrine cells. Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. Hear about promising developments in pancreatic cancer research in this excerpt from a Facebook Live event with Dr. Christine Alewine of NCI’s Center for Cancer Research and Dr. Lynn Matrisian of the Pancreatic Cancer Action Network. Many NCI-funded researchers at the NIH campus, and across the United States and world, are seeking ways to address pancreatic cancer more effectively. Location: 21 locations, The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. This study will also evaluate the antitumor effect of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab. Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. This phase I / II trial studies the side effects and best dose of BMS-813160 when given together with nivolumab and to see how well they work with or without GVAX following chemotherapy and radiation therapy in treating patients with pancreatic cancer … Pancreatic neuroendocrine tumors are less common but have a better prognosis. To achieve its research goals, each year NCI issues grants to support investigator-initiated research, to conduct clinical trials, and to support initiatives that address health care disparities. The 2017 figure represents the most recent data available from the NCI – and shows a remarkable 900 percent increase since PanCAN’s … NCI funds and oversees both early- and late-phase clinical trials to develop new treatments and improve patient care. Drugs used in chemotherapy, such as gemcitabine hydrochloride, nab-paclitaxel, fluorouracil, leucovorin calcium, and liposomal irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Nearly 50,000 Americans will be diagnosed with pancreatic cancer in 2015, according to NIH’s National Cancer Institute (NCI). Location: 9 locations, Treatment Clinical Trials for Pancreatic Cancer, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients with Pancreatic Cancer That Has Spread, Testing the Use of the Usual Chemotherapy before and after Surgery for Removable Pancreatic Cancer, Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients with Pancreatic Cancer That Has Spread with Inherited BRCA Mutations, Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens. Location: 11 locations, This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. Blocking PARP may help keep tumor cells from repairing their damaged DNA, causing them to die. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. However such drugs are now becoming available, such as a drug that targets a form of RAS that has a mutation called G12C. Dr. Alewine conducts clinical trials … This phase II trial studies how well niraparib and dostarlimab work in treating patients with germline or somatic BRCA1/2 and PALB2 mutated pancreatic cancer that has spread to other places … There is no reliable biomarker for early detection, and the available treatments are ineffective in advanced stages of this disease. She is leading a clinical trial testing the combination of LMB-100, a drug developed in CCR by the Pastan Lab that is designed to kill cancer cells, and nab-paclitaxel, a drug used to treat … Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. In this trial, people with cancer are assigned to receive treatment based on the genetic changes found in their tumors through genomic sequencing and other tests. Adenocarcinoma with variants of small intestine (closed to accrual 05 / 10 / 2018) 6. The most recent information from the NCI shows pancreatic cancer … Clear cell ovarian cancer (closed to accrual) 46. The Developmental Therapeutics Clinic is an NCI clinic that supports the work of the Division of Cancer Treatment and Diagnosis (DCTD). Perivascular epithelioid cell tumor (PEComa) 39. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07 / 27 / 2018) 2. Olaparib is an inhibitor of PARP, a protein that helps repair damaged DNA. Cediranib maleate and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Angiosarcoma 51. Location: 21 locations, This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1 / 2 / 3, ROS1, or ALK gene fusion. Apocrine tumors / extramammary Paget’s disease (closed to accrual) 40. Success in improving the outcome for pancreatic cancer patients requires better understanding of pancreatic … Pancreatic cancer can be hard to treat surgically due to the location of the organ, and because the disease has often spread in the body by the time it is diagnosed. Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. The exocrine type is more common and is usually found at an advanced stage. Clinical trials … Pancreatic cancer is often diagnosed at an advanced stage, for people usually have no symptoms until the cancer has already spread to other organs. Location: 13 locations, This is a Phase 3, randomized, double-blind trial to evaluate the efficacy and safety of neoadjuvant treatment with pamrevlumab or placebo in combination with gemcitabine plus nab-paclitaxel (G / NP) in the treatment of locally advanced, unresectable pancreatic cancer subjects. NCI-MATCH, also known as MATCH, is a precision medicine cancer treatment clinical trial.. Location: 16 locations, Brief Summary: The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) in combination with gemcitabine and nab-paclitaxel, for front line treatment of locally-advanced pancreatic adenocarcinoma.The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields (termed TTFields or TTF) to the region of the malignant tumor, by means of surface, insulated electrode arrays. Since the Recalcitrant Cancer Research Act was signed into law in 2013, when $101 million was dedicated to the disease, NCI research funding for pancreatic cancer has increased markedly. Pancreatic SPOREs. MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study. Spindle cell carcinoma of kidney, pelvis, ureter 20. In our urgent mission to save lives, we attack pancreatic cancer on all fronts: research, clinical initiatives, … Small cell lung cancer is not eligible (temporarily closed to accrual 03 / 25 / 2020) 52. Treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) As part of the Case Comprehensive Cancer Center, UH Seidman Cancer Center is a leading cancer research center and offers many clinical trials for patients with pancreatic cancer.This means that our patients have access to new and innovative therapies that are offered at few other cancer … Peritoneal mesothelioma (temporarily closed to accrual 05 / 08 / 2020) 41. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). This study may help doctors find out which treatment combination is better at prolonging life in older patients with metastatic pancreatic cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. Endometrial carcinosarcoma (malignant mixed Mullerian tumors) (closed to accrual) 45. This year’s symposium was jointly organized by the NCI Pancreatic Cancer … Because of the complex nature of pancreatic cancer, many experts believe it’s important for all patients to join a clinical trial, even if they have early-stage disease. Genomic sequencing is a laboratory method that is used to determine the genetic makeup of cancer … Carcinomas of pituitary gland, thyroid gland parathyroid gland and adrenal cortex (closed to accrual) 27. The clinical trials on this list are for pancreatic cancer treatment. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Advances in Pancreatic Cancer Research was originally published by the National Cancer Institute.”. See a full list of pancreatic cancer research projects that NCI funded in FY 2018. Clinical trials at the NIH Clinical Center are open to … Cediranib maleate may also block the flow of oxygen to the tumor, and may help make the tumor more sensitive to olaparib. Although few pancreatic cancer patients have, Researchers have found that drugs blocking the activity of proteins that mediate the effects of RAS, force cancer cells to rely on a way of creating energy called. Location: 21 locations, Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer. Clinical trials are research studies that investigate new treatments or new combinations of treatments. Chordoma (closed to accrual 11 / 29 / 2018) 31. A postdoctoral research position is available in the laboratory of Dr. Christine Alewine in the Clinical Translation Unit, Laboratory of Molecular Biology (LMB), CCR, NCI, NIH, Bethesda, MD. Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Eligibility: People ages 18 and older with pancreatic cancer, bile-duct cancer… Location: 16 locations, The objective of this study is to evaluate the safety, tolerability, and antitumor activity of oleclumab (MEDI9447) in combination with or without durvalumab plus chemotherapy in subjects with metastatic pancreatic cancer. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. Location: 482 locations, This phase III trial compares perioperative chemotherapy (given around the time of surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable / resectable). Pancreatic adenocarcinoma is not eligible 9. Center for Cancer Research National Cancer Institute Building 10 - Hatfield CRC, Room 3-3940 Bethesda, MD 20892-1201 Ph: 240-858-3080 SAR@nih.gov. Adenoid cystic carcinoma (closed to accrual 02 / 06 / 2018) 35. Odontogenic malignant tumors 22. NCI funding for pancreatic cancer research reaches more than $101 million – a 500 percent increase since our efforts began in 1999. Location: 15 locations, This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD / RD and regimen of XmAb23104, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb23104 monotherapy and combination therapy with ipilimumab in subjects with selected advanced solid tumors. Pancreatic cancer clinical trials are necessary to determine whether new treatments developed in the … Small cell carcinoma of the ovary, hypercalcemic type 49. The 5th NCI Pancreatic Cancer Symposium took place on October 2-3, 2018, and was attended by about 300 participants from across the United States and abroad. To find a safe dose of LMB-100 plus tofacitinib in people with pancreatic cancer, bile-duct cancer, and other solid tumors that make mesothelin. The following are some of our latest news articles on pancreatic cancer research: View the full list of Pancreatic Cancer Research Results and Study Updates. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Epithelial tumors of major salivary glands (closed to accrual 03 / 20 / 2018) 3. It conducts clinical trials of novel cancer treatment agents for … All trials on the list are supported by NCI. This trial enrolls participants for the following cohorts based on condition: 1. Location: 10 locations, This is a phase 1 / 1b study of TTX-030, an antibody that inhibits CD39 enzymatic activity, leading to accumulation of pro-inflammatory adenosine triphosphate (ATP) and reduction of immunosuppressive adenosine, which may change the tumor microenvironment and promote anti-tumor immune response. Location: 911 locations, This phase II trial compares two treatment combinations: gemcitabine hydrochloride and nab-paclitaxel, or fluorouracil, leucovorin calcium, and liposomal irinotecan in older patients with pancreatic cancer that has spread to other places in the body (metastatic). (closed to accrual) 23. Trials are available for pancreatic cancer treatment. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. Location: 13 locations, This is a Phase I / II, open-label, multi-center, multi-national, dose escalation, single agent study to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors harboring an NRG1 fusion. Standard treatment for pancreatic cancer usually consists of surgery, chemotherapy, radiation, or combinations of each, depending on the cancer’s stage. Basal cell carcinoma (temporarily closed to accrual 04 / 29 / 2020) 42. Effect of Tumor Treating Fields (TTFields, 150 kHz) as Front-Line Treatment of Locally-advanced Pancreatic Adenocarcinoma Concomitant With Gemcitabine and Nab-paclitaxel (PANOVA-3), A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Patients With Advanced Solid Tumors, Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy, Study of HPN536 in Patients With Advanced Cancers Associated With Mesothelin Expression, A Study of ASP1948, Targeting an Immune Modulatory Receptor, in Subjects With Advanced Solid Tumors, Evaluation of Efficacy and Safety of Neoadjuvant Treatment With Pamrevlumab in Combination With Chemotherapy (Gemcitabine and Nab-paclitaxel) in Locally Advanced Pancreatic Cancer, A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion, A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection, 5-fluorouracil / Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer, Compared to Nab-paclitaxel+Gemcitabine Treatment, A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3), A Study of XmAb®22841 Monotherapy & in Combination w / Pembrolizumab in Subjects w / Selected Advanced Solid Tumors, Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors, A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer), A Phase 2 Study of Cediranib in Combination with Olaparib in Advanced Solid Tumors, A Phase 1 / 2 Study of CYT-0851, an Oral RAD51 Inhibitor, in B-Cell Malignancies and Advanced Solid Tumors, TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers, A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies, U.S. Department of Health and Human Services. 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