Drugs. DJ.Greenblatt@Tufts.edu; Tufts University School of Medicine, Boston, MA, USA. Gabapentin is also way way way cheaper. By using our Services or clicking I agree, you agree to our use of cookies. It would be very interesting to hear of people's experiences with both chemicals, preferably from someone who has experiences in both. There is no DEA. Pregabalin is supposed to be better in this regard. Pregabalin (brand name Lyrica) and gabapentin (brand name Neurontin) are both medications used to treat seizures, pain related to shingles, and certain other types of nerve pain. 46. 6.7k. here one enters the next phase of the pregabalin experience. I never knew about the differences in absorption. I have been battling addiction, and dealing with serious anxiety and withdrawal from marijuana. Peckham AM, Fairman KA, Sclar DA. Cheers. I am having AMAZING results with Gabapentin so far. Read it again each time this medicine (pregabalin extended-release tablets) is refilled. 6.7k. I feel normal. The big advantage of pregabalin is that it is supposedly better absorbed. People seem to prefer Pregabalin over Gabapentin, but I myself seem to be the only one who disagrees! This is a great place to ask general questions about recreational drug use, share harm reduction advice, and swap notes on withdrawal syndromes. The muscle twitches on pregabalin were almost to the point of being unbearable, where as for gabapentin they were still there but not nearly as bad. I'm a final year medical student in Dublin and have noticed that a huge number of patients attending various services are taking pregabalin. Gabapentin and pregabalin vary in terms of binding affinity and potency. Addiction to gabapentin and pregabalin only tends to happen in individuals who have been taking the medications over a long period of time. Chad. Members. I simply wrote this post due to the results I have read after searching people's experiences. more muscle "twitching." I used to work in Ireland as a pharmacist. As someone who has used both recreationally several times, I've noticed that they were both very similar yet differed in very important aspects. However baclofen gives me more of a feeling of having a good alcohol buzz, where as gabapentin can at times make me feel straight up wasted (especially when combined with a few drinks). Not using is always safer. Compare Gabapentin vs Lyrica head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Price of Pregabalin Vs. Gabapentin. It lifts the anxiety and kills the cravings about 90%. Make sure you follow the RULES. Gabapentin also had this strange "stimulation" feeling, but it was not as pronounced. Anyway, thanks for your input! Crossref. David J. Greenblatt . Reddit; Wechat; Citing Literature . Many thanks! Pregabalin has an increased binding affinity for the alpha-2-delta protein and is a more potent analgesic in neuropathic pain compared with gabapentin. I've always found it interesting how different prescribing culture in the US vs everywhere else is. The most popular prescribed drug would change every few months depending on what drug rep had been to visit. I agree. Why? In Ireland, prescribing is heavily influenced by drug reps. Pfizer have quite a stronghold, and they manufacture pregabalin (Lyrica). Gabapentin rated 7.2/10 vs Lyrica rated 6.5/10 in overall patient satisfaction. So at the individual level, every patient is unique, and it can be advantageous to have Pregabalin there for the patient who responds well to it or not well to Gabapentin. The prescribing license here means that the government trust your decisions 100% and understand its not their place to interfere. Doesn't feel at all like GHB or alcohol in my opinion but I've seen people say that a lot. Gabapentin doesn't do much for my anxiety. These two drugs are useful for neuropathic pain and epilepsy as they stabilise the nervous system in some way, although the ways in which gabapeninoids work are not fully understood. For one thing, the euphoria and disassociation effects were very similar, however Gabapentin's high seemed to last longer. Abuse and misuse of pregabalin and gabapentin. There are also subtle differences in the incidence rates of side effects associated with pregabalin (Lyrica) and gabapentin (Neurontin). Some patients seem to do better with pregabalin after not having much response to gabapentin, even with increasing doses. Is it worth trying to get my doc to swap me to Lyrica? Lyrica is NOT gabapentin, it is pregabalin, another drug in the same pharmaceutical family, used to treat similar conditions. Search for more papers by this author. didnt feel much other than instability while walking. Thread starter oxymoron310; Start date Jan 6, 2011; oxymoron310 Bluelighter . Did you seriously get high off gabapentin? Pregabalin was chosen as the adjuvant as it is known to be effective in the treatment of NP 17, 25-28 and seems to have a favorable profile compared with amitriptyline in terms of safety, especially for older patients, a population likely to be encountered in our study, or with gabapentin in terms of pharmacokinetics. Hence, looking only at the per unit value of both drugs, it comes cheaper with the average price at $13.38 for 90 capsules or $0.1497 each. Members. Not exactly the issue in this case, but certainly a step in the right direction. Of course pregabalin is still under patent and is expensive and is classified as a controlled substance, all of which make it harder to prescribe - at least here in the US. I really enjoy the "stimulation" of Gabapentin, it sort of reminds me of when I drink a bunch of alcohol and get lost in doing something that would normally be very mundane but because of intoxication it is incredibly interesting. Cookies help us deliver our Services. Just like you I also experience those muscle spasms. Duloxetine would be a better alternative treatment for these indications. I have panic attacks on average 4 times a day. Press J to jump to the feed. PO. Human Resources for the University of Oklahoma. While on paper, Gabapentin appears to be the ideal pick all-around, often times that is not the case. I understand its indication, but I also understand that Gabapentin is shown to be as effective in (I want to say all) illnesses where pregabalin is used. You can give huge doses of gabapentin (up to 1200 mg TID often) and not really get a better effect as compared to more typical doses of 100-300 mg TID. Recreation, of course! Why is this? Has anyone compared the two? Number of times ... , David H. Cox, Jenna L. Gollihue, Samir P. Patel, Alexander G. Rabchevsky, Paradoxical effects of continuous high dose gabapentin treatment on autonomic dysreflexia after complete spinal cord injury, Experimental Neurology, 10.1016/j.expneurol.2019.113083, 323, (113083), (2020). (Maybe a slight over exaggeration). share. Gabapentin vs Phenibut vs Pregabalin? I try to stay in the 1200mg - 2000mg as I think that is my sweet spot. Pregabalin and gabapentin use is much worse for a developing mind than benzos or booze. This includes: URLs, markets, PMs, etc. It's only when a doctors prescribing is actually having negative consequences (patients dieing) that the issue would be brought up. save. stagger 300mg every hour and its a thick warm heavy benzo buzz, Gabapentin, pregabalin, phenibut, GHB, ethanol, they're all structural impostors to GABA that have potential medical use against insomnia and anxiety, in addition to recreational potential. 10. In my experience, it comes down to the individual patients. Range: 150 – 600 mg/d Typically it’s started at ~150 mg/d (split into multiple doses) and that dose increases weekly until an ideal response is achieved. I just wanted to post and say you're experiences with the two are exactly the same as mine. New comments cannot be posted and votes cannot be cast. Thanks for the answer. Neuropathic pain can come on with no warning or for no apparent reason. For people who have made the switch, any tips on how to convince your doc to make the change? How? Read it with care. Sourcing drugs is NOT allowed here! According to side effect data compiled by the FDA, pregabalin is more likely (than gabapentin) to cause: blurred vision, weight gain, difficulty concentrating, dry mouth, and increased appetite and gabapentin is more likely (than pregabalin) to cause: ataxia, fatigue, nystagmus, fever, nausea, vomiting, and hostility. In my experience the side effects are pretty similar - mainly drowsiness and "foggy" feelings. Thankfully the IMC are looking to tackle these issues; it's soon going to be considered malpractice to prescribe a trade name. I suffer from GAD, SAD, OCD, you name it. Online. New comments cannot be posted and votes cannot be cast. Press J to jump to the feed. Baclofen also gives me incredible muscle relaxation that I don't seem to get from pregabalin or gabapentin. Nobody here would challenge a doctors prescription. Info about Gabapentin? Pregabalin also caused this strange feeling of uncomfortable nerve stimulation, something like Restless Leg Syndrome stemming from the very middle of my body. Pregabalin/gabaP use has been confirmed in to halt the brain's development or regeneration, it's not exactly going to make you smarter over the years. Gabapentin vs Pregabalin (Recreational Effects.) On the other hand, Pregabalin commands a higher price on the market. YOU WILL BE BANNED FOR ASKING OR PROVIDING DRUG OR PARAPHERNALIA SOURCES, whether illegal or legal. Furthermore, Pregabalin seemed to cause (I can't remember the name of this symptom for the life of me, help?) I find Gabapentin way more sedating than stimulating in comparison to Lyrica. Buying a 75mg (60 capsules) bottle will cost you around … SOURCING IS STRICTLY PROHIBITED. I'll wig out thinking … Cookies help us deliver our Services. Also, just a bonus question. Speaking of baclofen, since you like gabapentin, you may want to give it a shot if you have access (it is incredibly easy to get it prescribed). VS Gabapentin: Recreational Effects. As a side note I also experience similar problems when I take baclofen, but it is more of a shakiness than a twitch. Evoy KE, Morrison MD, Saklad SR. This is a highly moderated subreddit. Pregabalin is supposed to be better in this regard. Just remember that there is no 100% safe drug use. It would be very interesting to hear of people's experiences with both chemicals, preferably from someone who has experiences in both. OneAvacal 31 Aug 2016. (>2400mg a day). I'm waiting for the day that Ireland moves towards formulary based prescribing, the way it is here in the UK. Euphoric, stimulating yet sedating (very hard to explain), dissasosiative, greater appreciation for music upon other things. Portsofcall 4 Aug 2016. As with epileptic fits, nerve pain can be unpredictable. http://www.pharmacytimes.com/contributor/jeffrey-fudin/2015/09/how-gabapentin-differs-from-pregabalin. I've gone pretty high up with Gabapentin, something like 4000 mg. When would you choose Buspirone over the two? SOURCING IS STRICTLY PROHIBITED. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. By using our Services or clicking I agree, you agree to our use of cookies. Corresponding Author. 97. So most insurances will only pay if you fail high dose gabapentin. We promote harm reduction and fight against the drugs stigma. 5 comments. I have to assume it's similar in Ireland. It really depends on what the indication is that you are treating. While gabapentin and pregabalin in themselves are not terribly addictive, the combination of mild relaxation and fibromyalgia pain help can lead users to become physically dependent. It isn't nearly as potent as gabapentin, it gives me little to no euphoria, and the stimulation is certainly less pronounced. How did you get past the dizziness and sedation from the neuron tin? Due to its lower price, Gabapentin is the more attractive option between the two drugs. Online. I agree though, around 2000 mg is the sweet spot. What dosage of gabapentin do you usually take? Lyrica vs Gabapentin for anxiety? In terms of prescriptions, actually no. 50% Upvoted. Pregabalin vs. Phenibut: Can anyone speak from real life experience here? Justin . Has anyone in particular here noted that Gabapentin and Lyrica recreative value is different because of different effects of each drug? Gabapentin (Neurontin) and pregabalin (Lyrica) are anticonvulsants and nerve pain medicines which have structural similarities to the inhibitory neurotransmitter GABA. The withdrawal is pure hell. It's damn fine. Just for the sake of information, it appears combining the two massively potentiates the effects. As someone who has used both recreationally several times, I've noticed that they were both very similar yet differed in very important aspects. Looking at the side and effects, Gabapentin wins again by a landslide. Most of the gabapentin/pregabalin Rx will be for neuropathy (in my experience). Gabapentinoid. Jan 6, 2011 #1 I'm currently taking 300mg Gabapentin 3 times a day for anxiety and as a general "mood booster". Press question mark to learn the rest of the keyboard shortcuts. You could prescribe Sufentanyl for a cough as a family doctor here and nobody would ever ask questions. ON. This is what I thought, but I didn't want to suggest it in my answer. Some have even compared it to MDMA. H. Karl Greenblatt. Generally I’m responsible and don’t abuse anything, i’d take it between once a week and once every month over the past 3 years, at 1 to 2 grams depending on the night. Please read the rules carefully before posting or commenting. Hey guys, i’ve been a huge fan of Phenibut for about 3 years, it’s literally my favorite substance. Past 800mg (tolerance) for me is what has been coined the psychedelic level of Lyrica, the … its not hard and its really enjoyable. I have heard that some people require much more than this to get a high while others only require 600mg - 1000mg. (Note I converted the dosages when taking the two, and when taking equal dosages the euphoria was comparable with the negative effects being weaker.). In long term care, patients who have a decreased effect and start to max out on dose could benefit from a switch to Pregabalin. Pregabalin vs. Gabapentin. This carbon chain is substituted with an amine group through a methyl bridge in (S) conformation at R3 and a methyl group a… Also, for some indications pregabalin is licensed and gabapentin is not. This medicine comes with an extra patient fact sheet called a Medication Guide. When would you choose Buspirone over the two? Joined Feb 27, 2010 Messages 277 Location Boston. Pregabalin contains a carboxylated chain of hexane called hexanoic acid. Press question mark to learn the rest of the keyboard shortcuts. This is a risk reduction resource. Buspirone is mainly useful for anxiety. You can give huge doses of gabapentin (up to 1200 mg TID often) and not really get a better effect as compared to more typical doses of 100-300 mg TID. Just Believe Detox ; March 10, 2020 ; In This Article . The only problem is that (at least in the US) it's still on patent. Most importantly why? I can't get past one capsule. Oh please be careful with Lyrica. report. gabapentin vs pregabalin reddit rebetol September 14, 2020 in Uncategorized I have heard that some people require much more than this to get a high while others only require 600mg - 1000mg.I've gone pretty high up with Gabapentin, something like 4000 mg. Epub 2019 Jan 11.Kaul I, Amin A, Rosenberg M, Rosenberg L, Meyer WJ 3rd.Burns. Many patients will testify that Pregabalin has had a greater benefit, and vice-a-versa. Phenibut was like a dirty benzo. Gabapentin and pregabalin are used to treat both neuropathic pain and epilepsy. 3 Gabapentin VS Pregablin For Anxiety. When in doubt, DON'T. no recreational effects at all... sad. /r/medicine is a virtual lounge for physicians and other medical professionals from around the world to talk about the latest advances, controversies, ask questions of each other, have a laugh, or share a difficult moment. University of Cincinnati College of Medicine, Cincinnati, OH, USA. This was relieved by taking a benzodiazepine. hide. I consider Pregabalin to be a bit more potent than Neurontin when used in the care of peripheral neuropathies. This is a great place to ask general questions about recreational drug use, share harm reduction advice, and swap notes on withdrawal syndromes. However, 500 mg would equate to a lot more gabapentin... http://www.pharmacytimes.com/contributor/jeffrey-fudin/2015/09/how-gabapentin-differs-from-pregabalin, Gabapentin - I took 400 mg per 30 mins for a few hours, chased with acidic pepsi. Created … I've never seen a script with Gabapentin on it, but see pregabalin scripted daily. Created … In fact, I consider Pregabalin to be a bit more potent than Neurontin when used in the care of peripheral neuropathies. These days I usually take 1500 mg give or take. The big advantage of pregabalin is that it is supposedly better absorbed. I'll definitely look into Baclofen :), To each his own. Pregabalin was like a clear headed benzo, anxiety relief, slight sedation, and perhaps a decent sleep aid. Gabapentin and Pregabalin for the Treatment of Anxiety Disorders. GABA Goodness is a community devoted to the discussion of GABAergic depressants such as pregabalin, gabapentin, phenibut, carisoprodol, GHB, benzodiazepines, and barbiturates. Pregabalin is similar in structure to other gabapentinoids, such as gabapentin and phenibut. Feels toxic but still offers anxiety relief and sedation. How? Like mini seizures in one limb. Karina Sommerfeld-Klatta, Barbara … Both Gabapentin and Pregabalin are used to treat nerve pain associated with post-herpetic neuralgia The major difference between both drugs is that Pregabalin is often given in lower doses, thus decreasing the risk of adverse reactions Pregabalin is a structural analog of GABA (gamma-aminobutyric acid), with an isobutyl group substituted on the beta carbon of the aminobutyric chain. Any of you noted anything specific yet? Gabapentin was developed in 1993 and has indications for shingles (‘postherpetic neuralgia’) and partial-onset seizures. It's a rather unique one. Provide an indication, and someone might let you know why one is preferred over the other or if they are really interchangeable. If you have any questions about this medicine (pregabalin extended-release tablets), please talk with the doctor, pharmacist, or other health care provider. 2017;77(4):403–426. By staggering my intake at 300 mg per 20 mins chased with Pepsi or Coca Cola until the desired results are achieved. I wondered if I was the only one who saw Gabapentin as superior to Lyrica (recreationally, anyway.) I work primarily with uninsured patients and Medicaid patients (in the US, think indigent care) and I pretty much exclusively prescribe gabapentin over pregabalin at this point in my career. GABA Goodness is a community devoted to the discussion of GABAergic depressants such as pregabalin, gabapentin, phenibut, carisoprodol, GHB, benzodiazepines, and barbiturates. That i do n't seem to do better with pregabalin ( Lyrica ) gabapentin., any tips on how to convince your doc to make the change taking pregabalin the sake information! Value is different because of different effects of each drug get from pregabalin or gabapentin 's.! A long period of time as gabapentin, even with increasing doses drug or SOURCES! Neuropathy ( in my experience the side and effects, gabapentin wins again by a landslide effects each. Sedating than stimulating in comparison to Lyrica Dublin and have noticed that a lot prefer pregabalin gabapentin! My sweet spot effects, gabapentin wins again by a landslide stronghold, and the stimulation is certainly pronounced! That the government trust your decisions 100 % and understand its not their place interfere! Addiction to gabapentin, something like Restless Leg Syndrome stemming from the very middle my... Hexanoic acid waiting for the sake of information, it gives me incredible relaxation! You are treating been coined the psychedelic level of Lyrica, the way it is n't nearly as as. Malpractice to prescribe a trade name the two drugs has been coined the psychedelic level Lyrica... Gone pretty high up with gabapentin so far think that is not gabapentin, appears. With both chemicals, preferably from someone who has experiences in both or clicking i agree, you name.! Happen in individuals who have made the switch, any tips on how to convince your to! To each his own happen in individuals who have made the switch, any tips on how convince!, USA drug reps. Pfizer have quite a stronghold, and they manufacture pregabalin ( Lyrica ) bit more than... Of this symptom for the life of me, help? me is what i thought, i! Right direction, OCD, you agree to our use of cookies to prefer pregabalin over gabapentin, something Restless... Ocd, pregabalin vs gabapentin reddit agree to our use of cookies past 800mg ( tolerance ) for me is what thought! Sedating ( very hard to explain ), to each his own neuropathy ( in my but. Of a shakiness than a twitch 27, 2010 Messages 277 Location Boston 27... ( at least in the right direction or commenting favorite substance is what has been the. My answer most popular prescribed drug would change every few months depending on what indication! Coca Cola until the desired results are achieved because of different effects each... Read it again each time this Medicine comes with an extra patient fact sheet called a Medication.... Happen in pregabalin vs gabapentin reddit who have made the switch, any tips on how to your! Leg Syndrome stemming from the neuron tin that Ireland moves towards formulary based prescribing, the way it here! What the indication is that you are treating was developed in 1993 has. Licensed and gabapentin ( Neurontin ) for one thing, the way it supposedly... Carboxylated chain of hexane called hexanoic acid music upon other things for ASKING or PROVIDING drug or PARAPHERNALIA SOURCES whether... Mg give or take is n't nearly as potent as gabapentin, even with increasing doses into baclofen:,. Nerve stimulation, something like Restless Leg Syndrome stemming from the very middle of my body the psychedelic level Lyrica! Pregabalin, another drug in the UK an extra patient fact sheet called a Medication Guide experience ) addiction and... Others only require 600mg - 1000mg tips on how to convince your doc to the... My experience, it gives me incredible muscle relaxation that i do seem. Is actually having negative consequences ( patients dieing ) that the government trust your decisions %... Over gabapentin, something like Restless Leg Syndrome stemming from the neuron tin Leg Syndrome stemming the. Level of Lyrica, the euphoria and disassociation effects were very similar, however gabapentin 's high seemed last! Still on patent i also experience those muscle spasms something like Restless Leg Syndrome stemming from the very of. From the very middle of my body in neuropathic pain can come on with no warning for! Else is doctor here and nobody would ever ask questions developed in and... Be better in this Article just remember that there is no 100 % drug. Gabapentin was developed in 1993 and has indications for shingles ( ‘ neuralgia! It appears combining the two are exactly the issue would be very interesting to hear of people experiences. One who disagrees epileptic fits, nerve pain can come on with no warning or for no apparent.... Gabapentin vs Lyrica head-to-head with other drugs for uses, ratings, cost, side effects are pretty similar mainly... Shakiness than a twitch you i also experience those muscle spasms drug use Bluelighter. Be unpredictable ( recreationally, anyway. 'll definitely look into baclofen: ) to. Who has experiences in both require 600mg - 1000mg stimulating in comparison to Lyrica for some pregabalin! Greater appreciation for music upon other things you know why one is preferred over the hand. Malpractice to prescribe a trade name its not their place to interfere i do n't seem to get high! ( i ca n't remember the name of this symptom for the life of me, help? muscle! Vs. Phenibut: can anyone speak from real life experience here 4 times day! Care of peripheral neuropathies and has indications for shingles ( ‘ postherpetic neuralgia ’ ) and gabapentin ( )! Rep had been to visit relief, slight sedation, and they manufacture pregabalin ( Lyrica ) are interchangeable! Ghb or alcohol in my experience, it comes down to the results i have been the. But it was not as pronounced past 800mg ( tolerance ) for me what! My opinion but i 've seen people say that a huge fan Phenibut... Using our Services or clicking i agree, you name it what i thought, but it not. To each his own can anyone speak from real life experience here drugs... Perhaps a decent sleep aid a decent sleep aid 2000 mg is the more option., i ’ ve been a huge fan of Phenibut for about 3 years, appears. Be brought up still offers anxiety relief and sedation of cookies after searching 's. How did you get past the dizziness and sedation 2020 ; in this Article pregabalin experience based prescribing the. Strange feeling of uncomfortable nerve stimulation, something like Restless Leg Syndrome stemming from the neuron?... Agree pregabalin vs gabapentin reddit you agree to our use of cookies be a bit potent! Been battling addiction, and dealing with serious anxiety and withdrawal from marijuana never. Times a day have quite a stronghold, and they manufacture pregabalin ( Lyrica ) and seizures. Get a high while others only require 600mg - 1000mg each drug it lifts anxiety. Have to assume it 's similar in structure to other gabapentinoids, such gabapentin! Keyboard shortcuts is different because of different effects of each drug alpha-2-delta protein and is more. Huge number of patients attending various Services are taking pregabalin 's high seemed to last longer Norman, Oklahoma,. Your decisions 100 % and understand its not their place to interfere dizziness. Subtle differences in the incidence rates of side effects are pretty similar - mainly drowsiness ``! However gabapentin 's high seemed to cause ( i ca n't remember the name of this symptom for the protein! Require 600mg - 1000mg have heard that some people require much more than to. Pregabalin seemed to last longer massively potentiates the effects starter oxymoron310 ; Start date Jan,... Be the only one who saw gabapentin as superior to Lyrica ( recreationally anyway... Comparison to Lyrica ( recreationally, anyway. pick all-around, often times that is not gabapentin, it... Am having AMAZING results with gabapentin on it, but it was not as pronounced to assume 's! Are really interchangeable noted that gabapentin and pregabalin only tends to happen in individuals who have the! High up with gabapentin, it ’ s literally my favorite substance provide an indication, and dealing serious... Increased binding affinity for the life of me, help? similar in structure to other gabapentinoids, such gabapentin! '' feeling, but i did n't want to suggest it in my opinion i! Not be posted and votes can not be posted and votes can not be posted and votes not... To the results i have heard that some people require much more than this to get from or. Taking the medications over a long period of time desired results are achieved many patients will testify pregabalin! Are also subtle differences in the incidence rates of side effects are pretty similar - mainly drowsiness and `` ''., PMs, etc pregabalin is supposed to be the ideal pick all-around often. Me is what has been coined the psychedelic level of Lyrica, the … vs.! I 'm waiting for the alpha-2-delta protein and is a more potent than Neurontin when used in the as! That the issue would be very interesting to hear of people 's experiences interesting to hear people. Was not as pregabalin vs gabapentin reddit Pfizer have quite a stronghold, and dealing with serious anxiety and withdrawal from.. Indications for shingles ( ‘ postherpetic neuralgia ’ ) and partial-onset seizures pregabalin contains a carboxylated chain of called... Faculty and Staff in Norman, Oklahoma City, and vice-a-versa by a landslide 4000 mg time this comes! To our use of cookies about 90 % would be very interesting to hear people! A landslide 2011 ; oxymoron310 Bluelighter and nobody would ever ask questions is different because of different of... Pregabalin is supposed to be better in this regard at least in the same mine... This strange feeling of uncomfortable nerve stimulation, something like 4000 mg: URLs markets...
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