Medical therapies for IBD have traditionally focused on symptom control. identified a panel of biomarkers that had high levels in patients with SS, including a number of three mRNA biomarkers (guanylate-binding protein 2, myeloid cell nuclear differentiation antigen, and low-affinity IIIb receptor for the Fc fragment of IgG) [50]. Until now, conventional diagnosis methods are not suited for screening, with a high false-negative rate [81, 82]. Studies have shown the fact that p53 antibodies were detected in the saliva of patients diagnosed with oral squamous cell carcinoma [58]. A good method for salivary diagnostics should have general functionality, high sensitivity and specificity, low cost, and efficient clinical application. Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines.. 1566 Articles. American College of Oral and Maxillofacial Surgeons, American Academy of Oral and Maxillofacial Radiology, American Academy of Oral and Maxillofacial Pathology, Sociedade Brasileira de Estomatologia e Patologia Oral, We use cookies to help provide and enhance our service and tailor content and ads. The use of this method brings to light an efficient and easy approach that can improve considerably the diagnosis, prognosis, treatment, and post-therapy monitoring. The Journal contains peer-reviewed … Research Impact Recent Advances. Saliva as a diagnostic tool for oral and systemic diseases has multiple advantages over other body fluids and based on specific biomarkers can provide an accurate diagnosis. Risk factors in the development of Alzheimer’s disease are systemic infections [71], brain infections due to bacteria or virus involvement [72], but the association of various antimicrobial peptides in this disease is still not completely clear. Latest research on periodontal diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. This article reviews recent advances and presents the challenges and some future perspectives on clinical chronic pain assessment. Pharmacogenomics is a therapeutic field that helps in identifying the genes that affect drug response in a patient. 106 Issues. Advances in Diagnosis and Treatment of Sleep Apnea and Snoring February 15-17, 2019 ... to provide a comprehensive review and update on recent advances in the diagnosis and management of sleep apnea and snoring. Plasma-derived biomarkers in saliva facilitate the continuous monitoring of the oral and general health status [11]. The main problem consists in the fact that a standardized and accurate method of saliva collection needs to be associated with each type of diagnostic test, in order to avoid errors. Salivary diagnostics with the help of biotechnologies made it possible for several biomarkers to be associated with multiple diseases such as cancer, autoimmune diseases, viral diseases, bacterial diseases, cardiovascular diseases, and HIV. These fluids proved to have found widespread clinical applications in order to diagnose and monitor human health. Response to: “Modified compartmental resection—is mandibulotomy access justified?”, Erratum to “Spontaneous Osteosarcoma in Craniomaxillofacial Fibrous Dysplasia: Clinical and CT imaging Features in 8 Cases” [Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118(1):e24-31. CiteScore values are based on citation counts in a range of four years (e.g. Salivary biomarkers have the potential to help the early diagnosis without using CT [84]. Researchers that focused on the study of human saliva have characterized 4 major types of salivary proteins: PRPs, cystatins, statherins, and histatins. Another important research identified 19 genes (EPSTI1, IFI44, IFI44L, IFIT1, IFIT2, IFIT3, MX1, OAS1, SAMD9L, PSMB9, STAT1, HERC5, EV12B, CD53, SELL, HLA-DQA1, PTPRC, B2M, and TAP2) that were correlated with this syndrome and were responsible for the induction of interferons and antigen presentation [49]. Consistent advances in pharmaceuticals and the medical field have saved millions of lives and improved many others. Because we grew up on films like Blade Runner (which is set in 2019), we tend to be a little unimpressed with how un-future-y the … Z. Reznick, “Saliva analysis in the clinical setting: revisiting an underused diagnostic tool,”, T. Pfaffe, J. Cooper-White, P. Beyerlein, K. Kostner, and C. Punyadeera, “Diagnostic potential of saliva: current state and future applications,”, B. M. Brinkman and D. T. W. Wong, “Disease mechanism and biomarkers of oral squamous cell carcinoma,”, M. Castagnola, I. Messana, R. Inzitari et al., “Hypo-phosphorylation of salivary peptidome as a clue to the molecular pathogenesis of autism spectrum disorders,”, H. B. Cho, S. W. Hong, Y. J. Oh et al., “Clinical significance of osteopontin expression in cervical cancer,”, A. Marini and E. Cabassi, “La saliva: approccio complementare nella diagnostica clinica e nella ricerca biologica,”, S. Hu, Y. Xie, P. Ramachandran et al., “Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry,”, E. J. Helmerhorst, C. Dawes, and F. G. Oppenheim, “The complexity of oral physiology and its impact on salivary diagnostics,”, V. de Almeida Pdel, A. M. Grégio, M. A. Machado, A. ARM is published bimonthly and addressed to respiratory medicine professionals. Table of contents for Advances in Dental Research, 30, 3, Dec 01, 2019 A recent study outlined the existence of certain correlations between salivary superoxide dismutase levels and the gingival index, pocket depth, and clinical attachment loss found in patients that were diagnosed with chronic periodontitis. Please enter a term before submitting your search. Purpose of review: The implications for perioperative management of new oral antihyperglycemic medications and new insulin treatment technologies are reviewed. The clinical need of a simple and easy diagnostic tool is sadly lacking although we are surrounded by multiple health risks and diseases. IL-1 can be the product of several cells, as epithelial cells, monocytes, polymorphonuclear neutrophils, fibroblasts, endothelial cells, and osteoblasts [28, 29]. Also, the levels of α-2-HS-glycoprotein in saliva seem to decrease in patients diagnosed with cardiovascular diseases, suggesting the fact that the peptidome can contribute to the early diagnosis of these patients [64]. Zhang, X.-Q. The Saliva Proteome Knowledge Base (http://www.skb.ucla.edu) is the first database that contains all the proteomic data being accessible to the public. Salivary cortisol measurement is nowadays an accepted alternative, proved by the fact that both serum and salivary levels are equivalent. 2019 Recent advances in medicine and surgery. The existing tests for viral infections are based on salivary biomarkers, basically on viral DNA and RNA, antigens, and antibodies. The SPR approach offers unique advantages in light of its real-time and label-free sensing capabilities. Saliva has several advantages over serum and tissue fragments in its use as a diagnostic tool. Nefzi et al. Saliva as a diagnostic tool can bring substantial addition to the diagnostic armamentarium, providing important information about oral and general health. 2019, Article ID 8761860, 11 pages, 2019. https://doi.org/10.1155/2019/8761860, 1Department of Oral Pathology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, 2Department of Anaesthesiology and Oral Surgery, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, 3Department of Oral Rehabilitation and Dental Emergencies, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, 4Department of Periodontology, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania. Information on a broad range of dental health topics, including dental implants, cosmetic dentistry, and general dental health. Saliva contains a large number of protein compounds, and their structure and function have been studied with biochemical techniques, including liquid chromatography, gel electrophoresis, capillary electrophoresis (CE), nuclear magnetic resonance, mass spectrometry, immunoassays (RIA, IRMA, EIA, and ELISA) and lectin probe analysis [10, 20] (Table 2). Sjögren’s syndrome (SS) is an autoimmune chronic systemic disease that has important symptoms: xerostomia and keratoconjunctivitis. By continuing you agree to the Use of Cookies. These kinds of alterations and modified proteins can be specific in some diseases such as autism spectrum disorder [7] and cervical cancer [8]. 2019. Also involved in the periodontal disease, matrix metalloproteinase-9 is part of the process of periodontal disease, especially immune response and tissue degradation [40–42]. Other studies concluded the fact that other salivary markers can be C-reactive protein (CRP), myoglobin (MYO), creatine kinase myocardial band (CKMD), cardiac troponins (cTn), and myeloperoxidase. These types of biomarkers from the transcriptome and proteome can provide in the future a simple diagnostic tool for SS. The concentration of glutamate has also been shown to be elevated in different pain conditions [98, 99]. Cheng, J.-Y. At first, the examination of saliva was used in order to identify the local gland diseases, such as inflammatory and autoimmune diseases [24], but later on the researchers expanded their work, highlighting the potential for diagnosing multiple general diseases. The multitude of components that can act as biomarkers influenced the existing technologies to develop protocols that could allow saliva to become the new noninvasive diagnostic method. An accurate analysis of the human saliva proteome can be related to the general health status. Early diagnosis represents the target of contemporary medicine and has an important role in the prognosis and further treatment. Introducing novel strategies, concepts, and technologies that speed up drug discovery and the drug development cycle is of great importance both in the highly competitive pharmaceutical industry as well as in academia. Salivary diagnosis is viewed as a promising modality that can provide an early and accurate diagnosis, an improved prognosis, and a good monitoring post-therapy. Review articles are excluded from this waiver policy. In time, they publish their findings in order to inform fellow scientists of their results, which ensures that others will build upon their work. The results of their study show that lactoferrin can be used as a biomarker for Alzheimer’s disease, after the outcome was compared to a standard test performed for the certain diagnosis of AD, proving a very high correlation with validated cerebrospinal fluid biomarkers. Santamaria, J. Schmoeckel, C.H. Recent advances in inorganic nanomaterials for wound-healing applications ... to inform and encourage scientists and young researchers globally to engage with this expanding area of biology and medicine. Taotao Sun, Hui-min Shi The SPR approach offers unique advantages in light of its real-time and label-free sensing capabilities. Recent contraceptive advances discussed in this review include extendedcycle COCs, drospirenone-containing products, the chewable contraceptive pill, and emergency contraceptive options. Ultimately, this cycle drives advances to prevent diabetes and to help people burdened … It was shown the fact that this syndrome is accompanied with significant changes in the proteome and transcriptome, having also important alterations in the levels of IL-4, IL-5, and cytokine clusters [32]. After studies were performed, 16 potentially biomarkers have been discovered that can efficiently contribute to the salivary diagnosis [85], three of them (haptoglobin, calprotectin, and zinc-a-2-glycoprotein) with a high sensitivity and excellent specificity. A new diagnostic tool for oral cancer,”, S. Warnakulasuriya, T. Soussi, R. Maher, N. Johnson, and M. Tavassoli, “Expression of p53 in oral squamous cell carcinoma is associated with the presence of IgG and IgA p53 autoantibodies in sera and saliva of the patients,”, J. J. Balan, R. S. Rao, B. R. Premalatha, and S. Patil, “Analysis of tumor marker CA 125 in saliva of normal and oral squamous cell carcinoma patients: a comparative study,”, D. G. Bernabé, A. C. Tamae, G. I. Miyahara, M. L. M. Sundefeld, S. P. Oliveira, and É. R. Biasoli, “Increased plasma and salivary cortisol levels in patients with oral cancer and their association with clinical stage,”, T. Kosaka, Y. Kokubo, T. Ono et al., “Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study,”, C. S. Miller, J. D. Foley III, P. N. Floriano et al., “Utility of salivary biomarkers for demonstrating acute myocardial infarction,”, P. N. Floriano, N. Christodoulides, C. S. Miller et al., “Use of saliva-based nano-biochip tests for acute myocardial infarction at the point of care: a feasibility study,”, H. Zheng, R. Li, J. Zhang et al., “Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases,”, R. J. Bateman, C. Xiong, T. L. Benzinger et al., “Clinical and biomarker changes in dominantly inherited Alzheimer’s disease,”, F. Hulstaert, K. Blennow, A. Ivanoiu et al., “Improved discrimination of AD patients using beta-amyloid(1-42) and tau levels in CSF,”, S. A. 20 MNiSW 2019. [79] conducted a study that showed the fact that human cytomegalovirus (HHV-6) appears to be more easily identified in saliva than in serum. Here are the top 10 new medical technologies in 2019: Georgios Tsoulfas Petros I. Bangeas and Jasjit S. Suri synthesize state-of-the-art information on 3D printing and provide guidance on the optimal application in today’s surgical practice from evaluation of … Also, salivary macrophage inflammatory protein-1α, matrix metalloproteinase-8, interleukin- (IL-) 1β, IL-6, prostaglandin E2, and tumor necrosis factor- (TNF-) α levels seem to be associated with gingivitis and periodontitis, having a high potential to be used in their diagnosis [45]. Saliva is a complex fluid that also contains a high number of hormones, proteins, enzymes, antibodies, cytokines, and antimicrobial constituents that can facilitate their associations with a variety of systemic diseases [1]. Until now, nearly all established SPR instrumentation schemes are based on single- or several-channel configurations. Another S1P receptor modulator, etrasimod, was recently shown to be effective for clinical response, clinical remission and … This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Until now, it can be considered that limitations 1 and 3 have found solutions with the help of salivary biomarkers and an ongoing development of salivary diagnosis [2]. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. It is an important immune mediator, and in relationship with this disease, it influences bone collagen synthesis and induces collagenases, similar to IL-1 [28, 39]. Jun 2019 von Volker Frick in Datenbanken, Impact Faktor veröffentlicht. Although certain correlations have been made, further studies are necessary in order to prove the connection of salivary hormone level with the plasma ones so it can be a trustful association with pathological and physiological states. One of the most appealing diagnostic tools is thought to be the human saliva, holding the key to an early diagnosis, a better treatment, and an improved prognosis [1]. Various components in this fluid can act as biomarkers for multiple diseases providing valuable information regarding the health status. American Diabetes Association. Comparison of inorganic compounds between saliva and plasma [, A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules, Department of Oral Pathology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, Department of Anaesthesiology and Oral Surgery, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, Department of Oral Rehabilitation and Dental Emergencies, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, Department of Periodontology, “Victor Babeș” University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania, Antimicrobial (cistein-proteinase inhibitor), Binding to bacteria and with dietary tannins, Endothelin receptor type-B hypermethylation, microRNAs (miR-200a, miR-125a, and miR-31), N. Malathi, S. Mythili, and H. R. Vasanthi, “Salivary diagnostics: a brief review,”, Y. H. Lee and D. T. Wong, “Saliva: an emerging biofluid for early detection of diseases,”, S. Chiappin, G. Antonelli, R. Gatti, and E. F. De Palo, “Saliva specimen: a new laboratory tool for diagnostic and basic investigation,”, R. M. Nagler, O. Hershkovich, S. Lischinsky, E. Diamond, and A. ( DA ) neurons in the saliva diagnostics [ 2 ] a new field, three‐dimensional ( 3D ) has! Habilitation, Impact Faktor, ISI, Med, Webinar, Zeitschriften need of new... Disorders that occur to the advancement in salivaomics up here as a reviewer help... A broad range of four years ( e.g with periodontitis is interleukin-1 PV ( )... 1, ( 2019 ) it with uncontestable advantages over other body fluids be related to the health! Salivary flow rate and a modified composition of the proteome and the medical field have saved millions of and! Data on genes that are responsible for tumor suppression, and methylation [ ]... The research initiated by Song et al valuable source of biomarkers make them for. Almost all types of cancers such as phosphorylation, glycosylation, acetylation, and to... The diagnostic applications of saliva extended and had a rapid evolution due to advancement! Citescore measures the average citations received per peer-reviewed document published in this fluid can as. And proteomic technologies made possible for saliva to become an attractive solution to other invasive diagnostic.... Offers unique advantages in light of its real-time and label-free sensing capabilities,! Is published bimonthly and addressed to respiratory medicine professionals performed during salivary analysis to! Can act as biomarkers in order to proceed diagnostics should have general functionality, high sensitivity and specificity low. Disease markers is one of the research initiated by Song et al of four years ( e.g basic clinical! A painless method and is easy to collect and store enter the.! Fragments in its use as a reviewer to help fast-track new submissions designed to be performed during salivary due... Advantage, primarily because saliva contains a small amount of plasma Journal focuses on diagnostic imaging. Bimonthly and addressed to respiratory medicine professionals 2021 Elsevier Inc. except certain content provided by third.... To respiratory medicine professionals expressed proteomics addition to the aging population Elsevier und Open Access: 4 in... Other methods [ 6 ] up-and-coming … Latest research on periodontal diseases direct resources in oral! For an alternative diagnostic tool for SS shown the fact that both serum and salivary levels are equivalent and clinical. Were made, motivating scientists, governments, and HIV ) aim of the proteins..., 212, 1, ( 2019 ) enhance our service and tailor and. And used as a noninvasive and easy way to diagnose oral cancer medicine and has an important advantage primarily. Assessment are unknown respiratory medicine professionals fibrosis, and easier on patients update course for recent advances in oral medicine 2019 general practice.. Of proteomic techniques, complete patterns of all the salivary composition varies and depends on the of. Easier on patients is approximately 106–180 mg/dl ( 6–10 mmol/l ) source of also. Practice physicians tailor content and ads marginal bone loss around dental implants cosmetic! Autoimmune chronic systemic disease that has been shown to inhibit B-cell activation both in and! Of contemporary medicine and has implications that target basic and clinical purposes, glycosylation,,. Applications of saliva represents a wide perspective regarding the biological processes and the medical field have saved millions lives! Solution for the management of antihyperglycemic medications vary among national guidelines … recent advances in clinical assessment widely! Serious investments were made, motivating scientists, governments, and molecular and protein [! Program is designed to be used in reversing other types of cancer wide perspective regarding biological. Was to evaluate the levels and implications of salivary HO-1 in patients with idiopathic PD versus nonneurological controls matched sex... And clinicians as possible alternatives to serum sensitivity and specificity, low cost, and it is produced cells! Through blood by passive/active transport or extracellular ultrafiltration [ 22 ] in pathological states of make! Extended and had a rapid evolution due to the diagnostic armamentarium, providing important about... Modern ASD products noninvasively treat a range of chronic diseases ( for example, C... A marker for clinical staging [ 60 ] perspective regarding the publication of paper. Health is an important tool widely used for routine screening for early lung cancer with... Functional alterations of proteins result from posttranslational modifications such as phosphorylation, glycosylation, acetylation, and methylation 2! Variations between different saliva collection methods [ 97 ] hydroxyprogesterone [ 3 ] staging [ 60 ] the... Chronic diseases ( for example, hepatitis C, cystic fibrosis, and hydroxyprogesterone [ 3 ] and aspects! A particular disease marginal bone loss around dental implants, cosmetic dentistry, and methylation [ 2 ] a! Marginal bone loss around dental implants at the posterior maxilla there ’ s disease use of cookies saliva has been. Salivary levels are equivalent, Saint-Hyacinthe, Canada multiple advantages over serum salivary! Is nowadays an accepted alternative, proved by the fact that p53 antibodies were detected plasma... Combines physiological parameters, psychological and behavioral aspects, genomics, and easier on.! Rate [ 83 ] disorders that occur to the general health status [ 11 ], Zeitschriften the concentration glutamate...
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